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There are several matches for 'serine/threonine kinase'.
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4947 matches
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organism
protein
1)
Homo sapiens
MARK2 - Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual ac [...]
[a.k.a. PAR-1, UPI0000048D8A, ENSP00000437509,
serine/threonine kinase
]
2)
Mus musculus
Map3k10 - Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway.
[a.k.a. XM_017322287.1, mixed lineage kinase 2, Map3k10-204,
serine/threonine kinase
]
3)
Homo sapiens
RIPK1 - Receptor-interacting serine/threonine-protein
kinase
1;
Serine
-
threonine
kinase
which is a key regulator of both cell death and cell survival. Exhibits
kinase
activity- dependent functions that trigger cell death and
kinase
-independent scaffold functions regulating inflammatory signaling and cell survival. Initiates ripoptocide which describes cell death that is dependent on RIPK1, be it apoptosis or necroptosis. Upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, [...]
[a.k.a. R-HSA-2562578, CH471087, R-HSA-5357786]
4)
Homo sapiens
NEK1 - Serine/threonine-protein
kinase
Nek1; Phosphorylates
serines
and
threonines
, but also appears to possess tyrosine
kinase
activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly.
[a.k.a. BAB15207.1, NM_001199399, KIAA1901]
5)
Homo sapiens
PRKCI - Protein
kinase
C iota type; Calcium- and diacylglycerol-independent
serine
/
threonine
- protein
kinase
that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...]
[a.k.a. 3ZH8, 6ILZ, ENST00000295797]
6)
Homo sapiens
STK16 - Serine/threonine-protein
kinase
16; Membrane-associated protein
kinase
that phosphorylates on
serine
and
threonine
residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein
kinase
toward other proteins.
[a.k.a. AF203910, ENSP00000386928, BC053998]
7)
Homo sapiens
STK24 - Serine/threonine-protein
kinase
24 12 kDa subunit; Serine/threonine-protein
kinase
that acts on both
serine
and
threonine
residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...]
[a.k.a. 4U8Z, 4QO9, 3A7G]
8)
Homo sapiens
STRAP -
Serine
-
threonine
kinase
receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...]
[a.k.a. R-HSA-170834, B2R5S5, R-HSA-162582]
9)
Homo sapiens
TTK - Dual specificity protein
kinase
TTK; Phosphorylates proteins on
serine
,
threonine
, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
[a.k.a. MPS1L1, NP_001160163, ENST00000502580]
10)
Homo sapiens
TTBK1 - Tau-tubulin
kinase
1; Serine/threonine
kinase
which is able to phosphorylate TAU on
serine
,
threonine
and tyrosine residues. Induces aggregation of TAU.
[a.k.a. Tau tubulin kinase, Q2L6C6, 84630]
11)
Homo sapiens
NEK9 - Serine/threonine-protein
kinase
Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on
serine
and
threonine
residues and beta-casein on
serine
residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively.
[a.k.a. R-HSA-69278, ENST00000238616, ENST00000555961.1]
12)
Homo sapiens
PAK5 - Serine/threonine-protein
kinase
PAK 5; Serine/threonine protein
kinase
that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several
serine
and/or
threonine
residues. Phosphorylates the proto-oncogene RAF1 and stimulates its
kinase
activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphoryla [...]
[a.k.a. EAX10359.1, CHEMBL4524, PAK5_HUMAN]
13)
Homo sapiens
DYRK3 - Dual specificity tyrosine-phosphorylation-regulated
kinase
3; Dual-specificity protein
kinase
that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated
kinases
(DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on
serine
and
threonine
residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phospho [...]
[a.k.a. O43781, 2.7.12.1, NM_001004023.1]
14)
Homo sapiens
AKT2 - RAC-beta serine/threonine-protein
kinase
; AKT2 is one of 3 closely related serine/threonine-protein
kinases
(AKT1, AKT2 and AKT3) called the AKT
kinase
, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through
serine
and/or
threonine
phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...]
[a.k.a. ENSG00000105221, R-HSA-388396, OTTHUMG00000137375]
15)
Homo sapiens
AKT1 - RAC-alpha serine/threonine-protein
kinase
; AKT1 is one of 3 closely related serine/threonine-protein
kinases
(AKT1, AKT2 and AKT3) called the AKT
kinase
, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through
serine
and/or
threonine
phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...]
[a.k.a. R-HSA-388396, AKT1-219, R-HSA-450604]
16)
Homo sapiens
AKT3 - RAC-gamma serine/threonine-protein
kinase
; AKT3 is one of 3 closely related serine/threonine-protein
kinases
(AKT1, AKT2 and AKT3) called the AKT
kinase
, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through
serine
and/or
threonine
phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...]
[a.k.a. R-HSA-388396, R-HSA-9006925, R-HSA-69278]
17)
Homo sapiens
CSNK2A1 - Casein
kinase
II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein
kinase
complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated
serine
or
threonine
. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...]
[a.k.a. ENST00000609525, 6A1C, 3PE2]
18)
Homo sapiens
CSNK2A2 - Casein
kinase
II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein
kinase
complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated
serine
or
threonine
. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...]
[a.k.a. 3OFM, R-HSA-9006925, R-HSA-69278]
19)
Homo sapiens
CSNK2A3 - Casein
kinase
II subunit alpha 3; Probable catalytic subunit of a constitutively active serine/threonine-protein
kinase
complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated
serine
or
threonine
. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
[a.k.a. Casein kinase II subunit alpha 3, CSNK2A1P, NP_001243615]
20)
Homo sapiens
PRKG1 - cGMP-dependent protein
kinase
1; Serine/threonine protein
kinase
that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates
serines
and
threonines
on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...]
[a.k.a. NM_006258.4, R-HSA-162582, CCDS7244]
4947 matches
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